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Thus, we see that the request that the client made is a combination of the FORM target and the data associated with the list box selection We can also see that there's some encoding and reformatting of the data when the request is made The main point here, however, is that a dynamic page can be generated through a GET request You probably already know how GET requests are constructed from HTML forms and how parameters are encoded But did you realize that the responses to GET requests with parameters can be cached In fact, they can, and this has obvious important performance implications As long as the server properly indicates it as cacheable, a dynamically generated GET response can be delivered faster to the requestor, without incurring additional server load This support is built in to HTTP 11 As an application designer, all you need to do is make sure that the HTTP responses include the proper header information to indicate to the client and the intermediate network elements that the data can be cached The way to do this is with the Expires HTTP header field For example, a server can return a result that includes the following information:

Detection points for the MO-SMS state model Description The subscriber has sent the short message or the SMS command to the MSC or SGSN There are no conditions prohibiting the SMS or command submission The CAMEL service is started A failure has occurred in the SMS or command submission The failure may have occurred internally in the MSC or SGSN or may have occurred externally, eg in the SMSC The short message or SMS command is successfully submitted to the SMSC

73 PARALLEL ARTIFICIAL-MEMBRANE PERMEABILITY ASSAY (PAMPA) 731 Egg Lecithin PAMPA Model (Roche Model)

HTTP/11 200 OK < other header fields > Expires: Fri, 1 Jan 2010 00:00:00 GMT <HTML> <HEAD></HEAD> <BODY>

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Kansy et al [547,550] from Hoffmann-La Roche published a widely read study of the permeation of drugs across phospholipid-coated lters, using a technique they coined as PAMPA, which stands for parallel arti cial-membrane permeability assay Their report could not have come at a better time just when the paradigm was shifting into screening for biopharmaceutic properties at high speeds, along side the biological screening In the commercial version of the PAMPA assay, a sandwich (Fig 79) is formed from a specially-designed 96-well microtiter plate [pION] and a 96-well micro lter plate [several sources], such that each composite well is divided into two chambers: donor at the bottom and acceptor at the top, separated by a 125mm-thick micro lter disk (045 mm pores, 70% porosity, 03 cm2 cross-sectional area), coated with a 10% wt/vol dodecane solution of egg lecithin (a mixed lipid containing mainly PC, PE, a slight amount of PI, and cholesterol), under conditions that multilamellar bilayers are expected to form inside the lter channels when the system contacts an aqueous buffer solution [543] The Roche investigators were able to relate their measured uxes to human absorption values with a hyperbolic curve, much like that indicated in Caco-2

which indicates that the response is valid until Friday, January 1, 2010 If the user bookmarks this page and returns to it, he'll get the cached copy Or he can type the same URL into the browser location bar (this works for IE 55 and Netscape 4x on Windows) It's only if he clicks on the browser Reload button that he'll get a refreshed copy There's a very important difference between Last-Modified and Expires for caching Web content With the Last-Modified approach, the browser always checks with the server to see if a new copy of the requested document has been generated If there are networking problems at the client site, Last-Modified won't work (it won't be able to contact the server) and the user will notice the hanging However, with the Expires approach the cached copy of the document is reused, independent of network availability There's a very important consequence to this: Once a document has an Expires tag associated with it, there's no requirement that the client refetch it until that Expires date is reached This means that, even if we make an important change to the document, we have no right to request that the client refetch it we're stuck with our original date We've seen how the HTTP GET method can be used to fetch static and dynamically generated content from the server We've also seen that careful use of additional optional header fields can prevent redundant data transfers and use information already in a cache Later, we'll see that HTTP 11 caching model is even more complex than we've discussed thus far and contains additional mechanisms to encourage caching of information at several levels Before we get into that topic, let's look at the second most popular way Web clients interface with servers

or more individual SMs through the network Each SMS of a concatenated SMS will trigger its own CAMEL service CAP IDP-SMS does not contain an indication that the SMS is part of a concatenated SMS

PARALLEL ARTIFICIAL-MEMBRANE PERMEABILITY ASSAY (PAMPA)

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